Effects of incretin in the treatment of type 2 diabetes
10.3760/cma.j.issn.1000-6699.2010.08.032
- VernacularTitle:肠促胰素在2型糖尿病治疗中的作用
- Author:
Linong JI
- Publication Type:Journal Article
- Keywords:
Incretin;
Glucagon-like peptide-1;
Glucose-dependent insulinotropic peptide;
Diabetes mellitus,type 2
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(8):后插1-后插4
- CountryChina
- Language:Chinese
-
Abstract:
Incretin hormones are defined as intestinal hormones released in response to nutrient ingestion,and potentiate the glucose-induced insulin response. In humans, the incretin effect is mainly caused by two peptidehormones, glucagon-like peptide-1 ( GLP-1 ) and glucose-dependent insulin releasing polypeptide (GIP). According to the recently finished studies, the review focuses on the physiological actions of incretin, explains the different insulinotropic actions of GLP-1 and GIP in type 2 diabetic patients, and evaluates the clinical features of recently approved therapeutic agents based on incretin action.
