Etiological Characteristic and Drug Resistance of Two Strains of Rhodotorula glutinis Found in ICU
- VernacularTitle:重症监护病房分离2株黏红酵母菌病原学特征及耐药性分析
- Author:
Xiaoou WU
;
Hong XU
;
Jie ZHAO
- Publication Type:Journal Article
- Keywords:
Rhodotorula glutinis;
Infection;
Drug resistance
- From:
Chinese Journal of Nosocomiology
2009;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To discuss the mycology characteristic of two strains of Rhodotorula glutinis causing infection in ICU,and conduct molecular biological identification and antifungal agent sensitivity experiment.METHODS The methods used included conventional mycology identification and sequencing the ITS region of strains,and the in vitro antifungal agent sensitivity experiment were done by glutinis liquid-based dilution method(M27-A).RESULTS The two strains of R.glutinis were confirmed after mycology identification and sequenced the ITS region of strains.They were both sensitive to amphotericin B and 5-flucytosine,and insensitive to fluconazole,itraconazole and voriconazole.CONCLUSIONS The reasons causing Rh.glutinis infection include catheter related infections,(total parenteral nutrition TPN) and immunosuppressives.Using amphotericin B and removing intravenous catheter can be the first choices in the treatment of Rh.glutinis infection.Azole shows insensitive to Rh.glutinis in the in vitro antifungal agent sensitivity experiment,therefore it should be used very carefully.
