Relationship Between Gene Frequency of HLA-DRB1*03 Genes and Expression of IL-18 in Chronic Hepatitis B Patients
- VernacularTitle:慢性乙型肝炎患者人类白细胞相关抗原DRB1基因频率与白细胞介素-18表达水平的相关性研究
- Author:
Hua JIANG
;
Qiaoxin HUANG
;
Yan LI
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
HLA-DRB1*03;
Interleukin-18
- From:
Chinese Journal of Nosocomiology
2009;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the relationship between HLA-DRB1*03 genes and expression of cytokine IL-18 in chronic hepatitis B patients.METHODS A total of 153 chronic hepatitis B patients and 138 normal healthy people were detected.HLA-DRB1*03 alleles were conducted in all the patients with polymerase chain reaction-sequence specific primer(PCR-SSP),and IL-18 was detected by ELISA.RESULTS Thirty-four individuals with chronic hepatitis B patients were HLA-DRB1*03 genes positive,the frequency was 22.22%,which was higher than the frequency of HLA-DRB1*03 in heathy individuals.The average level of IL-18 in chronic hepatitis B patients with HLA-DRB1*03 negatives was significantly higher than in HLA-DRB1*03 positives.CONCLUSIONS HLA-DRB1*03 closely relates with susceptibility to chronic hepatitis B.In chronic hepatitis B patients,the average level of Th1 cytokines in HLA-DRB1*03 negatives is higher than that in HLA-DRB1*03 positives.
