Antimicrobial Activity of Cefoperazine/sulbactam for Non-fermentative Gram-negative Bacilli
- VernacularTitle:头孢哌酮/舒巴坦对非发酵革兰阴性杆菌的抗菌活性
- Author:
Yanhua KUANG
;
Shuangquan LIU
;
Weiwei WANG
;
Jinhua XU
- Publication Type:Journal Article
- Keywords:
Non-fermentative Gram-negative bacilli;
Cefoperazine/sulbactam;
Drug resistance
- From:
Chinese Journal of Nosocomiology
2009;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the antimicrobial activity in vitro of cefoperazine/sulbactam for non-fermentative Gram-negative bacilli and analyze its antimicrobial capacity in vitro in comparison with imipenem and other antimicrobial drugs.METHODS The 362 clinical strains of non-fermentative Gram-negative bacilli were collected from Jun 1,2008 to Jun 1,2009.The drug resistance of the strains to 9 antibiotics was detected.RESULTS The primary non-fermentative Gram-negative bacilli were Pseudomonas aeruginosa,Acinetobacter baumannii,Stenotrophomonas maltophilia and Burkholderia cepacia in our hosipal.The resistant rates to cefoperazine/sulbactam were 29.2%,20.8%,25.0% and 27.3%,respectively.Cefoperazine/sulbactam was better than imipenem and meropenem and far better than piperacillin/tazobactam.CONCLUSIONS The resistant rate of non-fermentative Gram-negative bacilli is very high,and it shows multi-drug resistance.The results show cefoperazine/sulbactams is useful for non-fermentative Gram-negative bacilli infection with multi-drug resistance.
