Optimization of ?-Lactam Treatment Regimens for Extended-spectrum ?-Lactamases-producing Strains Infections Based on Pharmacokinetics/pharmacodynamics
- VernacularTitle:产超广谱?-内酰胺酶菌感染治疗方案的优化
- Author:
Guanghua YU
;
Tangxi CHANG
;
Wei SUN
;
Zhaoguo YI
;
Fang LI
- Publication Type:Journal Article
- Keywords:
Extended-spectrum ?-Lactamases-producing strain;
?-lactam;
Pharmacokinetics;
Pharmacodynamics;
Monte Carlo simulation
- From:
Chinese Journal of Nosocomiology
2009;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
MIC.RESULTS The bacteriostatic/bactericidal CFR of 0.5g q8h imipenem/cilastatin and 0.5g q8h meropenem were the highest(100%);that of 3.375g q4h sodium piperacillin/tazobactam sodium against ESBLs-producing E.coli was above 90%;the CFRs of ceftriaxone(1g q24h,2g q24h),ceftazidime(1g q8h,2g q8h),cefepime(1g q8h,1g q12h,2g q8h) and cefoperazone sodium/sulbactam(0.5g q8h,1g q8h,2g q8h) against ESBLs-producing strains were clearly less than those of non-ESBLs-producing ones,and the CFRs could not be effectively improved with the dose and frequency increased.CONCLUSIONS The PK/PD simulation is useful to optimize the regimen of anti-infective treatment,and guide its dosing accurately.
