Drug Resistance in ICU by Meticillin-resistant Staphylococcus aureus Infection and Effect of Linezolid
- VernacularTitle:耐甲氧西林金黄色葡萄球菌感染的耐药性分析及利奈唑胺治疗效果的研究
- Author:
Zhijie HE
- Publication Type:Journal Article
- Keywords:
Meticillin-resistant Staphylococcus aureus;
Nosocomial infection;
Resistance;
Linezolid
- From:
Chinese Journal of Nosocomiology
2009;0(22):-
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the drug resistance of the infection caused by meticillin-resistant Staphylococcus aureus(MRSA) in ICU and the effect of linezolid in the treatment on MRSA.METHODS The collection of sputum,blood,urine,cerebrospinal fluid,the top and local drainage of central venous needle in 3 years(2006 to 2009) in ICU was carried out,and the bacteriological culture and drug susceptibility testing were executed.Fifteen cases of MRSA infection patients were treated with linezolid.RESULTS There were 72 cases of MRSA infection in 3 years in ICU,most of them were drug-resistant.The sensitivity for MRSA infection was high to 100% by used with vancomycin,teicoplanin and linezolid.The trend of MRSA infection in ICU had increased in the past 3 years.The efficiency and recovery rates of linezolid group(73.3% and 33.3%,respectively) were higher than the vancomycin group(66.7% and 28.6%,respectively)(P
