Losartan reduces cardiomyocyte apoptosis in rats with heart failure
- VernacularTitle:氯沙坦降低心力衰竭大鼠心肌细胞凋亡
- Author:
Hong QIU
;
Hongfeng ZHU
- Publication Type:Journal Article
- Keywords:
heart failure;
angiotensin Ⅱ;
apoptosis;
BAX;
BCL-2
- From:
Basic & Clinical Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find the inpact(s) of Losartan on myocardial apoptosis in rats with heart failure. Methods Eight-week-old male SD rats were divided into control group(group C),heart failure(group HF) and treatment group(group LS). Use of doxorubicin injection model,group LS at the same time in a row to the oral losartan,myocardial ultrastructure was examined by TEM. DNA-situ terminal labeling (TUNEL method) was used to detect myocardial apoptosis and myocardial BAX,BCL-2 protein expression was detected by immunohistochemistry.ResultsGroup HF showed significant myocardial cell injury,and apoptotic bodies were found,serum CPK,CK-MB and LDH were increased. In LS group,myocardial apoptosis index was lower (P
