Detection of serum protein biomarkers by surface enhancedlaser desorption ionization time of flight mass spectrometry(SELDI-TOF-MS) in patients with non-small cell lung cancer
- VernacularTitle:SELDI-TOF-MS技术筛选NSCLC血清肿瘤标志物
- Author:
Yunbin YE
;
Ling CHEN
;
Zhilian SHE
;
Huijing CHEN
;
Dan CAI
;
Shuoyan LIU
;
Qiang CHEN
- Publication Type:Journal Article
- Keywords:
surface-enhanced laser desorption ionization time-of-flight mass spectrometry (protein fingerprinting);
carcinoma;
non-small cell lung cancer;
proteomics
- From:
Basic & Clinical Medicine
2006;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the characteristic of serum proteins in non-small cell lung cancer (NSCLC) patients,establish serum markers pattern for the diagnosis of NSCLC. Methods Surface enhanced laser desorption ionization time of flight mass spectormetry(SELDI-TOF-MS) technology was used to analyze serum samples. Biomarker Pattern Software (BPS) was used to detect the protein peaks. Results Sixteen significantly different protein peaks were found in serum samples in NSCLC patients and healthy controls. Eight up-regulated protein peaks and eight down-regulated protein peaks (P
