C type natriuretic peptide in femoral atery stenosis in diabetic rabbit models
- VernacularTitle:C型钠尿肽在糖尿病兔股动脉狭窄中的作用
- Author:
Lingqiang BAI
;
Chaozhong LIU
;
Jianwei TIAN
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide,C type;
Diabetes mellitus;
Femoral artery;
Rabbits
- From:
Chinese Journal of Interventional Cardiology
2003;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes in plasma C type natriuretic peptide(CNP) and C reaction protein(CRP) levels and the preventive effect of exogenous CNP on vascular stenosis in a diabetic rabbit model after femoral artery injury.Methods After setting up an animal model of diabetes,the rabbits were divided into the control group(n=8),artery injury group(n=8) and CNP treatment group(n=8).Enzyme-linked immunosorbent assay was used in determination of plasma CRP and CNP concentration.Histological changes in the femoral artery wall were evaluated by HE staining to determine the degree of stenosis.Results The post operative CRP concentration of the artery injury group compared with CNP treatment group was 13.81?4.30 ?g/mL vs 8.43?0.61 ?g/mL(P
