Experimental research on immunological rejection in embryonic brain tisssue transplantation
- VernacularTitle:胎脑组织移植免疫排斥反应的实验研究
- Author:
Jun LIU
;
Kecheng ZHANG
- Publication Type:Journal Article
- Keywords:
Brain;
Transplantation;
Rejection;
T-lymphocyte;
Major histocom-patibility complex
- From:
Chinese Journal of Organ Transplantation
1997;18(1):39-41,后插二
- CountryChina
- Language:Chinese
-
Abstract:
In order to study Whether there was rejection in brain tissue transplantation,the embryonic cerebral neoeortex from rat or mouse donors which were 16 to 18-day-old embryos was diffc!rent time after transplantation,the brain graft tissues were stained immunocytochemically to examine the expression of MHC-class Ⅱ antigens and subsets of T-cells.The results indicated that the survival rate of treatment group with immunosuppressant was higher than that of non-treatment group.Immunocytochemical evaluation showed that a large number of T-cells appeared. A significant increase of the number of class Ⅱ major histocompatibility complexes (MHC) expressing cells was found within and around the allografts.We conclude that the CNS is not an"immunologically privileged site"and there is graft rejection existing in brain transplanta-tion.It is necessary to treat brain transplant with immunosuppressant.
