Protective effects of estrogen on function of learning-memory and neuron of hippocampus in ovariectomized rats
- VernacularTitle:雌激素对去卵巢大鼠学习记忆功能及海马神经元的保护作用
- Author:
Lihui DUAN
;
Guoqing ZHOU
;
Jinxia LIU
- Publication Type:Journal Article
- Keywords:
estrogen;
ovariectomized;
tau protein;
hyperphosphorylation
- From:
Journal of Clinical Neurology
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the protective effects of estrogen on function of learning-memory and the neuron of hippocampus in the ovariectomized(OVX) rat model.Methods Estrogen 200 ?g/kg was injected into rats twice a weak followed the OVX rat models were estestablished(OVX+E2 group).The function of learning-memory was tested by Morris water maze;the tau hyperphosphorylation was detected by immunohistochemistry staining;the pathological changes of hippocampus was observed by HE staining and Bielschowski staining.Results Compared with OVX group,the function of learning-memory of Morris water maze in OVX+E2 group were significant improved(all P
