Changes of inflammation markers and restenosis following homemade sirolimus-eluting stent implantation
- VernacularTitle:国产雷帕霉素支架置入后血管再狭窄与炎症指标的变化
- Author:
Limei YAO
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(43):-
- CountryChina
- Language:Chinese
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Abstract:
BACKGROUND:Stent restenosis is a pathological process characterized by inflammatory healing response. Inflammatory cells play an important role in stent restenosis,thus,it can be controlled to reduce stent restenosis. OBJECTIVE:To observe the changes of high-sensitivity C-reactive protein (hs-CRP) and complement C3 before and after coronary stent implantation in patients with acute coronary syndrome,and to study the relation of inflammatory reactions and stent restenosis. DESIGN,TIME AND SETTING:A contrast observation was performed at the Department of Cardiology,People's Hospital of Xingtai between December 2005 and May 2009. PARTICIPANTS:A total of 65 patients with acute coronary syndrome and treated by percutaneous transluminal coronary intervention were collected. METHODS:According to coronary anglography,sirolimus-eluting stent (Firebird stent) was selected and implanted to cure acute coronary syndrome. MAIN OUTCOME MEASURES:Blood routine examination was performed before stent implantation and coronary anglography were used over a 6-month follow-up. The hs-CRP and complement C3 concentration was detected prior to,48 hours and 6 months after operation. RESULTS:Fifty-six patients were followed up,and the restenosis rate was 9% (5/56). The levels of hs-CRP,complement C3 in peripheral vein blood was obviously higher at 48 hours after implantation than prior to operation (P
