Effects of bone marrow mesenchymal stem cells administration on VEGF,SDF-1 and TGF-?1 expressions and heart function in myocardial infarcts rats
- VernacularTitle:骨髓间充质干细胞移植对大鼠心梗后细胞因子VEGF、SDF-1、TGF-?1表达及心脏功能的影响
- Author:
Yiqing WANG
;
Yuanpeng LI
;
Bingbo HOU
;
Jincun GUO
;
Peng ZHANG
- Publication Type:Journal Article
- Keywords:
stem cells;
cytokine;
myocardial infarcts;
cell transplantation
- From:
Basic & Clinical Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of bone marrow mesenchymal stem cells administration on VEGF,SDF-1 and TGF-?1 expressions and heart function in myocardial infarcts rats.Methods MSCs were harvested from SD rats,cultured and passaged in vitro,then the cells were purified by density gradient centrifugation and adhesive-screening method.Rats were randomly divided into 2 groups.In the control group(n=8) the animals were treated with saline of the same volume as placebo.Four weeks after the injection,the VEGF,SDF-1 and TGF-?1 expressions and heart function were examined.Results Four weeks after the transplantation,Immunohistochemistry showed expression of VEGF and SDF-1 increased markedly in experiment group,and expression of TGF-?1 decreased.Heart function was improved in the experiment group(P
