Role of two kinds of adipokines on hepatocellular apoptosis in mice with acute liver injury
- VernacularTitle:两种脂肪因子对急性肝损伤小鼠肝细胞凋亡的作用
- Author:
Hongzhu YIN
;
Caiyan ZHAO
;
Yinghui LIU
;
Yangai SONG
- Publication Type:Journal Article
- Keywords:
adiponectin;
leptin;
hepatocellular apoptosis;
acute liver injury
- From:
Basic & Clinical Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the interference role that two kinds of adipokines,adiponectin and leptin,exert to hepatocellular apoptosis in mice with acute liver injury induced by Concanavalin A(ConA).MethodsTwenty-six male BALB/c mice were divided into four groups randomly:ConA group(8 mice),adiponectin group(5 mice),leptin group(5 mice) and control group(8 mice).Mice were sacrificed 8 hours after ConA-treatment for observing hepatic injury and hepatocellular apoptosis.Results Comparison to ConA group,the mice in adiponectin group showed less hepatic injury and lower ALT level and less hepatocellular apoptosis(P
