Effects of fluctuant high blood glucose on the expression of apoptosis-related genes in neurons of hippocampus of diabetic rats
- VernacularTitle:血糖波动对糖尿病大鼠海马神经元凋亡相关蛋白表达的影响
- Author:
Wei LI
;
Juan SUN
;
Songlou YIN
;
Xiuqin LI
- Publication Type:Journal Article
- Keywords:
BCL-2;
BAX;
diabetes mellitus;
hippocampus;
apoptosis
- From:
Basic & Clinical Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of fluctuant high blood glucose on the pathology profile and BCL-2,BAX expression in neurons of the hippocampus from diabetic rats.Methods The diabetic rat models were developed by injection with l% streptozotocin(STZ),followed by insulin administration.Regular insulin was used to set up fluctuant high glucose group model.After 12 experimental weeks,the expression of Fas protein in hippocampus was checked by immunohistochemistry,pathological changes and ultrastructure were observed by using light microscopy and electron microscopy in three groups.Results Compared with those in N group,the expression of BCL-2 in pyramidal cells of diabetic rat's hippocampus was lower,while that of BAX was higher(P
