Apoptosis and mitochondrial membrane potential change of gastric smooth muscle cells in diabetic rats
- VernacularTitle:糖尿病大鼠胃平滑肌细胞凋亡与线粒体膜电位改变
- Author:
Hongxian ZHAO
;
Xia CHEN
- Publication Type:Journal Article
- Keywords:
diabetes;
gastroparesis;
apoptosis;
mitochondrial membrane potential;
cytochorome C
- From:
Basic & Clinical Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pathogenesis of gastroparesis in diabetic rats.Methods SD rats were randomly divided into control group and diabetes group.Ten weeks later,gastroparesis model was established.The apoptosis rate and mitochondrial membrane potential of the gastric smooth muscle cells were detected by flow cytometry.Cytochrome C was detected by immunohistochemistry.Results Compared with rats in control group:(1)Typical symptoms of diabetes mellitus appeared;The rate of gastric residual pigment was significantly higher(P
