Expression and significance of CD26/DPPⅣand galectin-3 in papillary thyroid carcinoma
- VernacularTitle:CD26/DPPⅣ、galectin-3在甲状腺乳头状癌的表达及意义
- Author:
Nianchun PENG
;
Xiaohui GUO
;
Zhenfang YUAN
;
Yanming GAO
- Publication Type:Journal Article
- Keywords:
papillary thyroid carcinoma;
CD26/DPPⅣ;
galectin-3;
metastasis;
prognosis
- From:
Basic & Clinical Medicine
2006;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance of CD26/DPPⅣand galectin-3 in papillary thyroid carcinoma.Methods Expression of CD26/DPPⅣ or galectin-3 in 68 papillary thyroid carcinomas and 36 thyroid adenomas were determined with EnVision immunohistochemical technique respectively.Results CD26/DPPⅣ and galectin-3 were highly expressed in most of papillary carcinomas but absent or expressed in a low level in most of all thyroid adenomas.With CD26/DPPⅣ as marker to detect papillary carcinoma,the sensitivity,specificity,diagnostic accuracy were 86.8%,97.2% and 90.4%,and with galectin-3 the respective figures were 97.1%,91.7% and 95.2%.There was no statistic significance in intrathyroidal and extrathyroidal invasion,with or without lymph node metastasis,low and poor prognosis groups about positive expression of CD26/DPPⅣ or galectin-3 in papillary carcinomas.Conclusion Both CD26/DPPⅣ and galectin-3 are potential markers of papillary thyroid carcinoma.CD26/DPPⅣ or galectin-3 immunohistochemical staining can be used as a supplement technology for routine pathological diagnosis to differentiate thyroid papillary carcinomas from adenomas,but not accepted as the bio-markers for the invasion,metastasis and prognosis of papillary thyroid carcinomas.
