Interleukin-6 and rheumatoid arthritis
- VernacularTitle:白细胞介素-6与类风湿性关节炎
- Author:
Shuxia WANG
;
Guoxiang FANG
;
Xiaojun LI
- Publication Type:Journal Article
- Keywords:
IL-6;
Arthritis;
Rheumatoid
- From:
Journal of Medical Postgraduates
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA) is an autoimmune disease(AID) characterized by arthrosynovitis.Cytokines are involved in the whole course of the disease.Such important cytokines as TNF-? and IL-1? play a key role in the proliferation of synovial cells and progression of inflammation,and,therefore,have been taken as clinical therapeutic targets for RA in the recent years.The blocking agent of TNF-? or IL-1? is effective for only a few patients and the increasing adverse events it causes,such as infection and malignancy,are arousing more and more concern.The abnormal expression and imbalance of interleukin-6(IL-6) are closely associated with RA.IL-6 is an important regulatory factor for the pathogenesis of RA,and the blocking agent may be applied to the treatment of the disease.
