Antioxidant status and products of oxidative stress in colorectal cancer
- VernacularTitle:结直肠癌患者体内氧化应激状态的评价及产物的分析
- Author:
Dong CHANG
;
Yashuang ZHAO
;
Hongzhi PAN
- Publication Type:Journal Article
- Keywords:
Colorectal cancer;
Oxidative stress;
DNA damage;
Lipid peroxidation;
Protein oxidation
- From:
Journal of Medical Postgraduates
2003;0(10):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Colorectal cancer is related to antioxidative ability and oxidative stress level.The aim of the study was to evaluate the oxidative stress in colorectal cancer patients and to investigate the relationship between oxidative stress and colorectal cancer.Methods:A total of 60 subjects(30 colorectal cancer patients,30 normal healthy controls) were examined in the study and estimated the protein oxidation,DNA damage,lipid peroxidation and antioxidants-vitamin C,vitamin E,glutathione(GSH) and antioxidative enzymes in serum,respectively.Results:Statistically significantly higher values of protein carbonyl and advanced oxidation protein products(AOPP) were observed in colorectal cancer patients(P
