Effect of 5-azacytidine and simulated biological microenvironment on differentiation from bone marrow mesenchymal stem cells into myocardial-like cells
- VernacularTitle:化学诱导剂5-氮杂胞苷及模拟生物微环境对骨髓间充质干细胞分化成心肌样细胞的影响
- Author:
Zhihui CHU
;
Jie HUI
;
Lianhua HAN
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(40):-
- CountryChina
- Language:Chinese
-
Abstract:
0.05) . Four weeks after culture,both transcription factor NKX-2.5 and GATA4 were expressed in the 5-azacytidine group. Additionally,?-mysion heavy chain but not ?-mysion heavy chain expression was observed. CONCLUSION:5-azacytidine induced the differentiation from bone marrow mesenchymal stem cells into myocardial-like cells;in addition,simulated biological microenvironment in both indirect contact group and myocardial cell lysate group also induced the same differentiation. The differentiated cells were cardiac possesses which were between mature cells and cardiac progenitor cells.
