Therapeutic effect of glycyrrhiza active substance on guinea pig model of vitiligo
- VernacularTitle:甘草活性成分对白癜风豚鼠模型的治疗作用
- Author:
Mingwei ZHOU
;
Rihua JIANG
;
Qi ZHANG
- Publication Type:Journal Article
- Keywords:
glycyrrhiza;
vitiligo;
models,animal
- From:
Journal of Jilin University(Medicine Edition)
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of glycyrrhiza active substance on guinea pig model of vitiligo,and to clarify its mechanism on promoting synthesis of melanin,and to provide the basis for its clinical application.Methods Guinea pigs decolorized by H2O2 were used as experimental models,and normal control group was set up.After treatment of glycyrrhiza active substance in three doses groups(20,40,and 80 mg?kg-1),the therapeutic effect was observed by visual observation,macrography,histological examination as well as immunohistochemical study.Results The significant differences of skin color among control group,model group and treatment groups were observed by macrography.The total effective rates in 40 or 80 mg?kg-1 groups were higher than that in control group(P
