Expressions of CK17 and P63 in human cervical cancer tissues and significances
- VernacularTitle:人宫颈癌组织中CK17和P63蛋白的表达及意义
- Author:
Songling ZHANG
;
Lihong ZHANG
;
Yanping ZHONG
;
Yulin LI
- Publication Type:Journal Article
- Keywords:
cervix uter;
neoplasms,squamous cell;
CK17;
P63;
neoplastic stem cells
- From:
Journal of Jilin University(Medicine Edition)
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of CK17 and P63 in cervical cancer tissues,and explore the possibility of CK17 and P63 as markers of cervical cancer stem cells.Methods The expressions of CK17 and P63 in cervical squamous cancer tissues(n=55) and normal cervix tissues(n=20) were detected with immunohistochemical method.Results ①CK17 expressed in reserve cell cytoplasm in normal cervical specimens.In the cervical cancer specimens,the expression of CK17 was increased and it seemed that CK17 was stained in the margin of the cancer nest and the tumor embolus.In specimens with high grade malignant cancer or after the chemotherapy,the expressions of CK17 were increased(P
