Inhibitory effects of triethyltin chloride on proliferation of rat C6 glioma cells in vivo and morphological changes
- VernacularTitle:氯化三乙基锡对体内大鼠C6胶质瘤增殖抑制作用及病理学改变
- Author:
Shi ZHANG
;
Yue ZHANG
;
Xiaoying BI
;
Zhichao LI
- Publication Type:Journal Article
- Keywords:
triethyltin chloride;
glioma;
cell proliferation;
apoptosis
- From:
Journal of Jilin University(Medicine Edition)
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the inhibitory effects of triethyltin chloride(TETC) on proliferation and the morphological changes of rat C6 glioma cells in vivo.Methods C6 glioma cells were autotransplanted into 16 Wistar rats,and the rats were divided into experiment group and control group.TETC was injected into each rat through intraperitoneal route at the dose of 1 mg?kg-1?d-1 and the injection lasted 4 d in experiment group,and the physiological saline was injected into each rat in the same way as experiment group in control group.The weights of C6 glioma were measured and the proliferation rate of the tumor was calculated after 14 d.The morphological changes of C6 glioma cells were observed by HE staining and electron microscope.Results The weight of C6 glioma in TETC group was lighter than that in control group(P
