Obtaining fetus of rhesus monkey with the combination of misoprostol and mifepristone
- VernacularTitle:联合使用米索前列醇和米非司酮以获取恒河猴胎猴样品
- Author:
Li ZHAO
;
Yuanyuan HAN
;
Donghong TANG
- Publication Type:Journal Article
- Keywords:
rhesus monkey;
mifepristone;
misoprostol
- From:
Basic & Clinical Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a safe and effective method for obtaining fetus of rhesus monkey.Methods The pregnant process of rhesus monkey was monitored by B ultrasonography,and the pregnant rhesus monkeys in different stages of pregnant were randomly chosen.Mifepristone was subcutaneously injected to pregnant rhesus while misoprostol was put to their posterior fornix.The efficacy of this method was evaluated by the results of bishop score,the rate of pregnancy termination and the quality of total RNA extracted from brain samples of rhesus fetus.ResultsThe scores of bishop score and rates of fetus delivery of experiment group were both higher than that of control group(P
