Thyroid hormone resistance with H435L mutation in exon 10 of thyroid hormone receptor ? gene associated with Hashimoto's thyroiditis
- VernacularTitle:甲状腺激素受体?基因第10外显子H435L突变致甲状腺激素抵抗并桥本甲状腺炎
- Author:
Xiaolan LIAN
;
Min NIE
;
Yao BAI
- Publication Type:Journal Article
- Keywords:
thyroid hormone receptor ? gene;
resistance to thyroid hormone;
Hashimoto's thyroiditis
- From:
Basic & Clinical Medicine
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
T),resulting in His to Leu(CAT→CTT) substituted at codon 435(H435L).No mutation was identified in the patient's parents.HT occurred in the patient during following-up.Conclusion H435L mutation in exon 10 of TR? gene leads to resistance to thyroid hormone.Meanwhile,consistent RTH might lead to HT.
