Paclitaxel loaded poly(ε-caprolactone)/poloxamer 188 blend microspheres and in vivo evaluation of its antitumor activity
10.3760/cma.j.issn.1673-4181.2009.06.001
- VernacularTitle:紫杉醇聚己内酯/泊洛沙姆188共混载药微球及其抗肿瘤活性
- Author:
Guilei MA
;
Cunxian SONG
- Publication Type:Journal Article
- Keywords:
Poly(ε-caprolactone);
Pluronic F68;
Paclitaxel;
Microspheres;
Antitumor activity
- From:
International Journal of Biomedical Engineering
2009;32(6):321-324,327
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare paclitaxel-loaded poly(ε-caprolactone)(PCL)/pluronic F68(F68)blend microspheres as a controlled release system. Methods Paclitaxel-loaded PCL/F68 blend microspheres were prepared by the oil-in water(O/W)emulsion/solvent evaporation method. Characterization of the microspheres followed to examine the particle size, the drug encapsulation efficiency, the surface morphology, in vitro release behavior and DSC analysis. In vivo antitumor activity of paclitaxel-loaded PCL/F68 blend microspheres was evaluated in mice bearing with hepatoma H22 cells ascites tumor. Results The results showed that the porous structure can be formed in the surface of PCL/F68 blend microspheres. Faster and controlled release of paclitaxel from PCL/F68 blend microspheres was achieved in comparison with the PCL microspheres. In animal tests, paclitaxel-loaded PCL/F68 blend microspheres showed the potent antitumor activity against hepatoma H22 cells in ascites tumor model. Conclusion The paclitaxel loaded PCL/F68 blend microspheres were found to own a faster release rate and a remarkably controlled release behavior.
