The level of ox-LDL correlates with the severity and risk factors of CHD
- VernacularTitle:氧化低密度脂蛋白与冠心病病变程度及其他危险因素的关系
- Author:
Weiwei ZHANG
;
Jianbin GONG
;
Junjun WANG
;
Shisen JIANG
- Publication Type:Journal Article
- Keywords:
Oxidized low density lipoprotein;
Coronary heart disease;
Risk factor
- From:
Journal of Medical Postgraduates
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: Oxidized low density lipoprotein(ox-LDL) plays an important role in the pathogenesis and development of atherosclerosis.The aim of this study was to explore the relationship of the ox-LDL level with the severity and risk factors of coronary heart disease(CHD).Methods: A total of 164 patients undergoing coronary angiography(CAG) were assigned to a control group(n=29) and a CHD group(n=135) according to the results of CAG.The samples of fasting plasma were collected,and the levels of ox-LDL were detected by ELISA.Based on different criteria of classification,the CHD patients were again divided into the following subgroups: acute myocardial infarction(AMI),unstable angina(UA),stable angina(SA),single-vessel disease(SVD),double-vessel disease(DVD),multi-vessel disease(MVD),localized lesion,diffuse lesion,slight stenosis group,moderate stenosis,and severe stenosis.Results: The level of ox-LDL was higher in the AMI(85.60 ? 29.21 ?g/ml) than in the UA(72.54 ? 27.75 ?g/ml) and SA groups(72.93 ? 26.50 ?g/ml),with statistically significant differences(P = 0.05 and P = 0.06).It was significantly higher in the MVD(83.78 ? 29.66 ?g/ml) than in the SVD group(68.57 ? 26.50 ?g/ml,P
