Adverse in utero environment can increase the risk of atherosclerosis in the offspring
- VernacularTitle:不利的子宫内环境增加子代动脉粥样硬化患病风险
- Author:
Yan LU
;
Junjun WANG
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Epigenetics;
Pregnancy;
Risk factor
- From:
Journal of Medical Postgraduates
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Epidemiological and pathological evidence has demonstrated that adverse in utero environment,such as protein restriction,hypercholesterolemia,diabetes and smoking,can increase the risk of vascular disease in the offspring.In utero,the placenta and fetus are exposed to the metabolic,antioxidant and pro-inflammatory and anti-inflammatory signals from the mother and likely to make specific responses,which may lead to permanent changes either in DNA methylation or chromatin modification or both,and these changes,in turn,may result in increased atherosclerosis susceptibility in adulthood.In this review,we briefly summarize the possible signals crossing the placental barrier and discuss the molecular mechanisms of epigenetic programming in the developing fetus that may lead to increased athero-susceptibility of the vessel wall.
