Roles of MMP-2 and MMP-9 in the central nervous system
- VernacularTitle:基质金属蛋白酶MMP-2、MMP-9在中枢神经系统中的作用
- Author:
Lei MAO
;
Handong WANG
- Publication Type:Journal Article
- Keywords:
Protease;
Neural development;
Spinal cord injury;
Central nervous system cancer
- From:
Journal of Medical Postgraduates
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
The matrix metalloproteinases(MMP) are important enzymes that regulate developmental processes,maintain normal physiology in adulthood and have reparative roles in specific stages after an insult to the nervous system.Conversely,the concordant presence and significant up-regulation of several MMP members in virtually all neurological conditions result in pathological lesions.Thus,the MMPs have double functions,capable of mediating repair and recovery on the one hand and being involved in producing injury on the other.This article highlights the beneficial roles of MMP-2 and MMP-9 in normal and reparative processes within the nervous system and discusses the detriments of both encountered in spinal cord injury and central nervous system cancers,and we also review the availability of MMP inhibitors for clinical use.
