Correlation of MMP and TIMP with osteosarcoma invasion and metastasis
- VernacularTitle:基质金属蛋白酶及金属蛋白酶组织抑制剂与骨肉瘤侵袭转移的关系
- Author:
Xianliao ZHANG
;
Xin SHI
- Publication Type:Journal Article
- Keywords:
Matrix metallopmteinase;
Tissue inhibitor of metalloproteinase;
Osteosarcoma;
Metastasis
- From:
Journal of Medical Postgraduates
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metallopmteinase(MMP),a family of proteolytic enzymes,can degradate the composition of extracellular matrix.Its structure,regulatory function and physiopathology have been deeply studied,and its role in tumor metastasis has received more attention.The tissue inhibitor of metalloproteinase(TIMP),as an endogenous MMP inhibitor,suppresses both the form and course of MMP activation.The function zone of its C-end accords with some other parts of MMP,forming an MMP-TIMP compound,to block the combination of MMP with the substrate,suppress the activation of MMP,and slow down or block the invasion and metastasis of osteosarcoma.
