Progress in Researches of Eph/ephrin Signaling in Coupling of Bone Resorption and Bone Formation
- VernacularTitle:骨吸收与骨形成耦联中Eph/ephrin信号转导的研究进展
- Author:
Juan ZHAO
;
Yingjie MAO
;
Zhiyuan GU
- Publication Type:Journal Article
- Keywords:
osteoclasts, osteoblasts, Eph receptors, ephrin ligands, bidirectional signal transduction
- From:
Progress in Biochemistry and Biophysics
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Osteoclastic bone resorption and osteoblastic bone formation are coordinated as a coupled mechanism to effect the development of bone and to maintain bone homeostasis. Recently reported Eph/ephrin bidirectional signaling between osteoclasts and osteoblasts plays a pivol role in bone homeostasis and casts new light on coupling of bone resorption and bone formation, which is gaining more and more attention in researches of bone biology and bone diseases. The present article aims to address the researches on the Eph/ephrin bidirectional signaling between osteoblasts and osteoclasts with molecular constitution, mechanism of the signal transduction, biological significance and so on.
