Advancement of chondrocyte proliferation and differentiation by paracrine and autocrine signaling pathway
- VernacularTitle:软骨细胞增殖与分化旁/自分泌通路的研究进展
- Author:
Biqing XIA
;
Xudong WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(37):-
- CountryChina
- Language:Chinese
-
Abstract:
In the process of chondrocytes development and maturation, the chondrocyte displayed great morphological and biochemical change under the control of kinds of growth factors and changeable environments, such as mechanical stress, or cell density changes. This change of characteristic chondrocytes is controlled by specified signaling pathways, and the autocrine and parocrine factors are playing an important role in the promotion of chondrogenesis. At present, the autocrine and parocrine familys are divided into following types, including the transforming growth factor ? family, fibroblast growth factor family, Hedgehog family, and Wingless family. However, the gene expression is not decided by the only one pathway, but the results of the cooperation of various signals. Therefore, the relationship between the pathways is going to be found and confirmed. To identify the effect of the each factor during the proliferation and differentiation of chondrocytes may direct the development of tissue-engineered cartilage.
