The Role of TGF?1 and IL-13 in Cellular Signal Transduction of Hepatic Fibrosis of Schistosomiasis
- VernacularTitle:TGF-?1与IL-13在血吸虫病肝纤维化细胞信号转导中的作用
- Author:
Jing LI
;
Wei WANG
;
Jilong SHEN
- Publication Type:Journal Article
- Keywords:
Hepatic fibrosis;
IL-13;
TGF-?1;
Signal transduction
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is characterized by an abnormal hepatic accumulation of extracellular matrix (ECM) that results from both increased deposition and reduced degradation of collagen fibres. Some studies show that transforming growth factor ?1(TGF-?1), alternatively activated macrophage (aaM) and interleukin 13(IL-13) play a key role in the evolution of fibrosis, of which TGF-?1 and IL-13 become research hotspots. TGF-?1 mainly activates hepatic stellate cells (HSC) through TGF-?1/Smad signal pathway, while IL-13 seems to play a rather crucial role through JAK-STAT6 signal pathway. aaM is an important source of TGF-?1 and activated with Il-13. This paper reviews the role of those signaling molecules in cellular signal transduction of hepatic fibrosis of schistosomiasis japonica, and provides some targets for future drug development.
