Effect and mechanism of arsenic trioxide on LRP mRNA expression in human lung adenocarcinoma cells in vitro
10.3760/cma.j.issn.1008-6706.2010.01.003
- VernacularTitle:三氧化二砷对人肺癌A549细胞凋亡及耐药基因表达的影响
- Author:
Dongqing ZHENG
;
Wanlan BO
;
Tao LIANG
- Publication Type:Journal Article
- Keywords:
Arsenic trioxide;
Lung neoptasms;
Genes;
Apoptosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(1):7-9,插5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanism of arsenic on human lung adenocarcinoma cells.Methods MTT,FCM and RT-PCR tests were used to investigate apoptosis levels induced by arsenic trioxide and the effect on LRP mRNA expression.Results 1.0μmol/L and 3.0μmol/L arsenic trioxide can decrease LRP mRNA expression.Conclusion Low concentration As_2O_3 may improve apoptosis of lung caner by decreasing LRP mRNA expression.As_2O_3 may be used to treat lung cancer but the results are not better than cisplatin.
