Effect of Rhubarb on Neurological Injury and Apoptosis in ICH rats

VernacularTitle:大黄酸对脑出血大鼠神经损伤和细胞凋亡的影响
Author: Ling CHEN ; Zhao HAN ; Wanhua HU ; Yinghao ZHI
Publication Type:Journal Article
Keywords: Intraccrebral hemorrhage; Rhubarb; Apoptosis
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(1):26-27,插6
CountryChina
Language:Chinese
Abstract: Objective The purpose of this investigation was to investigate the neuroprotective effects of rhubarb for ICH,as well as its mechanism.Methods ICH was produced in adult Spargue-Dawley rats by injection of collagenase IV(0.05U/0.5uL).Intraperitoneal injection of rhubarb (70mg/kg) or saline,was started at 3,6 or 12 hours post-ICH respectivdy.Casepase-3 activity.TUNEL and neurological behavior function were performed 24hours after ICH.Results Rhubarb siven at 3 or 6 hours can inhibit casepase-3 activity(P<0.001),reduce TUNEL positive cells(P<0.05) and attenuate apomorphine-induced rotation(P<0.05) at 24 hours after ICH.However,the animals which were treated 12 hours showed no improvement.Conclusion Rhubarb may be a potential drug for ICH patients for its possible effect of inhibiting apoptosis.