Protective effects of Astragaloside Ⅳ on blood-brain barrier and influence on expression of ZO-1 protein after cerebral ischemia-reperfusion in rats
- VernacularTitle:黄芪甲苷对大鼠脑缺血再灌注后血-脑屏障的保护作用及ZO-1蛋白表达的影响
- Author:
Youzhi QU
;
Min LI
;
Yanling ZHAO
- Publication Type:Journal Article
- Keywords:
cerebral ischemia;
reperfusion;
Astragaloside Ⅳ;
blood-brain barrier;
ZO-1 protein
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of astragaloside Ⅳ on blood-brain barrier(BBB) and influence on expression of ZO-1 protein after cerebral ischemia and reperfusion in rats.Methods 72 SD rats were randomly divided into:sham operation group,model group and two astragaloside Ⅳ therapy groups [group A(10 mg/kg,group B(20 mg/kg)].Method of Evans blue leakage and water content in the brain tissue were used to investigate the permeability of the BBB,and method of immunohistochemistry combined with image analysis was used to measure the expression of ZO-1 protein in microvessels.Results Compared with those in the model group,Evans blue leakage and water content were less and the number of ZO-1 possitive vessels was increased in the two astragaloside Ⅳ therapy groups.There were statistical differences between therapy groups and model group(all P
