Expression of interleukin-8 in the brain tissue and serum and the effect of Dexamethason in rats with local cerebral ischemic
- VernacularTitle:白介素-8在局灶性脑缺血大鼠脑组织及血清中的表达及地塞米松对其的影响
- Author:
Lin LI
;
Xia LI
;
Shaokuan FANG
- Publication Type:Journal Article
- Keywords:
focal cerebral ischemia;
interleukin-8;
Dexamethasone
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of interleukin-8(IL-8) in the brain tissue and serum and effect of Dexamethason in rats with local cerebral ischemic.Methods The rats were randomly divided into blank control group,shamoperated group,ischemic group and Dexamethasone group.The latter two groups were divided into 1 h,2 h,4 h,8 h,12 h,24 h,48 h,72 h after oppration groups,respectively,12 rats in each group.The cerebral ischemical models were made by thread-embolism.The expression of IL-8 in brain tissue and serum at each time point were detected by ELISA method.Results In the ischemic group and Dexamethasone group,the expression of IL-8 of the brain tissue and serum were increased gradually in 1 h after ischemia,and reached the perk in 24 h and 4 h respectively.Which were significantly lower than those in the blank control group or shamoperated group(all P
