Research of the Rho kinase in perihematomal cerebral tissue after experimental intracerebral hemorrhage
- VernacularTitle:实验性脑出血血肿周围组织中Rho激酶的研究
- Author:
Hongyan ZHANG
;
Fuqiang GUO
;
Hao SUN
- Publication Type:Journal Article
- Keywords:
intracerebral hemorrhage;
Rho kinase
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression of the Rho kinase in perihematomal cerebral tissue after experimental intracerebral hemorrhage(ICH) and the relationship between which and the neurological function deficit.Methods The ICH models rats were randomly divided into groups 1 d,3 d,5 d and 7 d after ICH.At the certain time point,the score of neurological function in each model was measured before killed.The expression of Rho kinase protein and mRNA were detected by immunohistochemistry and in situ hybridization.Results After ICH 1 d,3 d,5 d and 7 d groups,the scores of neurological function were 1.63,2.25,3.13 and 2.88,respectively;the number of Rho kinase protein positive cells in perihematomal cerebral tissue were 26.63,30.75,38.88 and 35.00,and the number of Rho kinase mRNA positive cells were 27.25,32.25,40.88 and 38.00,respectively.There were significantly differences among the groups 1 d,3 d and 5 d in the scores of neurological function and the expression of the Rho kinase protein and mRNA(P
