Expression of P-glycoprotein in brain tissue and peripheral blood in refractory epileptic rats with amygdale kindled by electricity and kainic acid
- VernacularTitle:杏仁核电点燃及海人酸点燃难治性癫大鼠脑组织及外周血P糖蛋白的表达
- Author:
Chunxiao YANG
;
Yue YANG
;
Jinfeng LI
- Publication Type:Journal Article
- Keywords:
refractory epilepsy;
P-glycoprotein;
amygdale;
electrical kindling;
kainic kindling
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the possible mechanism of over expression of P-glycoprotein(Pgp) in brain tissue and peripheral blood in refractory epileptic rats with amygdale kindled by electricity and kainic acid,and compare the expression tendency of Pgp in brain tissue and peripheral blood of the different ways to establish refractory epileptic rats models.Methods The models of refractory epileptic rats were made by electrical kindling and kainic kindling in amygdale.Group A was for amygdale-electrical-kindling rats(n=12),group B was for amygdale-kainic-kindling rats(n=12),group C was implanted electrode without kindling and Carbamazepine was given by gavage(n=8),group D was injected saline in amygdale and Carbamazepine was given by gavage(n=8),group E was implanted electrode without kindling and saline was given by gavage(n=8) and group F was injected saline in amygdale and saline was given by gavage(n=8).The expression of Pgp in brain tissue and peripheral blood was detected by immunohistochemistry in each group.Results The expression of Pgp in brain tissue and peripheral blood of rats in group A and B were both much higher than those in the other groups and there were statistical differences(all P
