Chenges and its significance of the levels of serum cytokines and C-reactive protein in patients with cerebral infarction
- VernacularTitle:脑梗死患者血清细胞因子和C-反应蛋白水平的变化及其意义
- Author:
Junxiang WEI
;
Zhifen WANG
;
Shigang ZHAO
- Publication Type:Journal Article
- Keywords:
cerebral infarction;
interleukin;
tumor necrosis factor-?;
C-reactive protein
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes and its significance of the levels of serum cytokines——interleukin-(IL)1?,IL-6,tumor necrosis factor(TNF)-? and C-reactive protein(CRP) in patients with cerebral infarction(CI).Methods The serum IL-1?,IL-6 and TNF-? level were detected by radioimmunnoassay and serum CRP level by immunoturbidimetry in 30 CI patients with DM(DMCI group),30 CI patients without DM(NDMCI group),20 patients with DM(DM group) and 20 normol controls(NC group).The situation of CI patients were assessed by modified Edinburgh-Scandinavian stroke scale(ESSS).Results The serum levels of IL-1? [(0.60?0.04)ng/ml,(0.33?0.03)ng/ml,(0.30?0.02)ng/ml],IL-6 [(231.07?7.68)pg/ml,(141.34?6.50)pg/ml,(118.92?5.82) pg/ml],TNF-?[(2.70?0.11)ng/ml,(1.85?0.11)ng/ml,(1.21?0.13) ng/ml] and CRP [(7.44?0.26),g/L,(4.67?0.21)mg/L,(4.54?0.24)mg/L] in DMCI group,NDMCI group and DM group were significantly higher than those in NC group [(0.20?0.03)ng/ml,(60.99?5.98)pg/ml,(0.70?0.10) ng/ml,(3.83?0.14) mg/L](all P
