Study of N-methyl-D-aspartic acid receptor 2B level and calcium/calmodulin-dependent protein kinase Ⅱ activities in the hippocampus of vascular dementia rats and the intervention effects of Memantine
- VernacularTitle:血管性痴呆大鼠海马N-甲基-D-天冬氨酸-2B亚基受体水平和钙/钙调蛋白依赖性蛋白激酶Ⅱ活性以及美金刚干预作用的研究
- Author:
Yu HE
;
Hang ZHAO
;
Yu ZHANG
- Publication Type:Journal Article
- Keywords:
vascular dementia;
N-methyl-D-aspartic acid receptor 2B;
calcium/calmodulin-dependent protein kinase Ⅱ;
Memantine
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate changes of N-methyl-D-aspartic acid receptor 2B(NR2B) level and calcium/calmodulin-dependent protein kinase Ⅱ(CaMK Ⅱ) activities in the hippocampus of vascular dementia(VD) rats and the intervention effects of Memantine.Methods The VD rat models were established by permanent,bilateral occlusion of the common carotid arteries.The rats were randomly divided into VD group and Memantine-treated group.At 4,8,12,16 weeks after operation,the water maze test was performed to detect the ability of learning and memory of the rats.The changes of NR2B level were measured by RT-PCR.The changes of the CaMK Ⅱ activities were determined by incorporation of 32P into histone.The resoults were compared with the sham-operated group.Results Compared with the sham-operated group,the ability of learning and memory of VD group rats at each time point after operation decreased significantly(all P
