Change and its correlation between plasma concentration of glutathione peroxidase and polymorphisms of glutathione peroxidase promoter gene in patients with acute cerebral infarction
- VernacularTitle:急性脑梗死患者血浆谷胱甘肽过氧化酶浓度的改变及其与GPx-3启动子基因多态性的关系
- Author:
Kaimei HUANG
;
Zhong ZHAO
;
Weixian CHEN
- Publication Type:Journal Article
- Keywords:
cerebral infarction;
glutathione peroxidase;
gene polymorphisms
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change and its correlation between plasma concentration of glutathione peroxidase and polymorphisms of the glutathione peroxidase(GPx-3) promoter gene in patients with acute cerebral infarction(ACI).Methods 94 patients with ACI and 80 normal controls were detected the concentration of plasma glutathione peroxidas.The patients with ACI were undertaken neural function deficient scale(NDS) after 1 d onset.GPx-3 gene polymorphism were detected using polymerase chain reaction and ligase detection reaction(PCR-LDR) in patients with ACI.Results Plasma glutathione peroxidase concentration in ACI group were lower than that in the normal control group in first day onset(P0.05).The plasma concentration of glutathione peroxidase and NDS in patients with mutation of GPx-3 promoter gene were obviously lower than those in the patients without mutation(P
