Effects of progesterone on Survivin in ishikawa endometrial carcinoma cell line
- VernacularTitle:孕激素对子宫内膜癌细胞系Survivin表达的影响
- Author:
Sumin QIAN
;
Huilan WANG
- Publication Type:Journal Article
- Keywords:
endometrial neoplasm;
progesterone;
proliferation;
apoptosis
- From:
Basic & Clinical Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of progesterone on apoptosis and Survivin expression protein of Ishikawa cell line of human endometrial carcinoma in vitro.Methods The proliferation of Ishikawa cells in vitro was determined by methyl thiazolyl terazolium (MTT) medhod.Cell cycle,apoptotic percentage were detected by cytometer. The expression of Survivin protein of Ishikawa cells was detected by immunocytochemistry. Results Progesterone inhibited the growth of Ishikawa cells significantly when the concentration of progesterone reached at 0.5?10-5～10-4mol/L(P
