Clinical analysis of dentinogenesis imperfecta type Ⅱ in a large Mongolian family
- VernacularTitle:蒙古族牙本质发育不全Ⅱ型一大家系临床分析
- Author:
Qizhu WU
;
Haihua BAI
;
Xinyuan ZHANG
;
Yujie CHEN
;
Haiping LIU
;
Changchun QIU
- Publication Type:Journal Article
- Keywords:
Mongolian;
dentinogenesis imperfecta type Ⅱ;
pedigree
- From:
Basic & Clinical Medicine
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To figure the clinical characteristics and genetic bases of Dentinogenesis imperfecta type Ⅱ in a large Mongolian family.Methods Systematic analysis for this family was carried out using clinical detection. Results Affected individuals of Dentinogenesis imperfecta type Ⅱ were consecutively found in a five-generation family. The morbidity of the offsprings is nearly 1/2 and no sexual difference is found. The analysis of clinical features as well as dental x-ray check showed specific finding that were not found in other families. Conclusion Dentinogenesis imperfecta type Ⅱ in this Mongolian family pertains to autosomal dominant disorder with high genetic heterogeneity in clinical phenotype. Further study is warranted to identify the association of this heterogeneity with lifestyle or genetic information.
