Preparation technique and biological performance of poly(lactic-co-glycolic acid) sustained-release microspheres
- VernacularTitle:乳酸-羟基乙酸共聚物缓释微球的制备工艺与生物学性能
- Author:
Rong BAI
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(34):-
- CountryChina
- Language:Chinese
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Abstract:
Microsphere of diameter 1-300 ?m is a biophysical target drug-loading reagent. Loading material of microspheres is classified into natural polymer,semisynthetic macromolecule,and synthetic macromolecule. Based on proper preparation technique and prescription,drug-loading microspheres made by synthetic macromolecule can release drug to a certain velocity during several weeks or months,reduce administration times,and enhance complaisance. Moreover,microspheres are ideal drug-loading system for protein and polypeptide drug. Research of microspheres is a hot topic at recent,thus more and more drugs are developed into microspheres. Poly(lactic-co-glycolic acid) (PLGA) characterizing by great security,good biocompatibility,and alterable biodegradation is a common material to make microspheres. There are three ways to establish PLGA sustained-release microspheres,including solvent evaporation method,spray drying method,and phase separation method. In particular,solvent evaporation method is frequently used to make PLGA microspheres loading polypeptide and protein in various medical fields of immunology,gene therapy,tumor therapy,bone defect repairing,and ophthalmology.
