Effect of Rosuvastatin on Microalbuminuria and Arteriosclerosis Plaque of Artery in Hypertensive Patients
- VernacularTitle:瑞舒伐他汀治疗原发性高血压患者尿微量白蛋白和动脉粥样硬化
- Author:
Xiaoling PENG
;
Zepeng LIN
;
Hong TENG
;
Rongkui ZHANG
;
Zhiwei ZHANG
- Publication Type:Journal Article
- Keywords:
Essential hypertension;
Rosuvastatin;
Microalbuminuria;
The intima media thickness of the common carotid artery
- From:
Chinese Journal of Hypertension
2006;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Background Rosuvastatin has been unanimously recognized as an very highly efficacious statin. Rosuvastatin significantly reduced microalbuminuria and its powerful anti-inflammatory effect confer anti-atherosclerosis in patients with essential hypertension. Objective To study the influence of rosuvastatin on microalbuminuria and arteriosclerosis plaque of carotid and coronary arteries in hypertensive patients. Methods Seventy-six hypertensive patients were randomly to receive conventional anti-hypertensive drugs (amlodipine 5 mg/d and telmisartan 80 mg/d,n=37) or rosuvastatin (10 mg QN) on the top of conventional anti-hypertensive drugs (n=39). The blood pressure,levels of microalbuminuria,echocardiography and helical computerized tomography were examined before and 8 months after treatment in all patients. Results After 8 months of treatment,SBP and DBP were decreased in both group [conventional treatment from (166.3?11.2)/(92.4?8.2) to (133.6?9.8)/(85.5?6.1)mmHg,combined group from (165.6?10.5)/(91.5?6.7) to (128.1?9.2)/(81.1?5.9)mmHg]. Combined treatment significantly reduced the levels of microalbuminuria [(31.6?21.8) to (23.2?19.8)mg/g,P
