Changes of Alpha Competitive Structure after Administration of Single Dose Methylphenidate in Children with Attention Deficit Hyperactivity Disorder
- VernacularTitle:注意缺陷多动障碍儿童服用单剂量哌甲酯后脑电?波的变化
- Author:
Li SUN
;
Yufeng WANG
;
Hua HE
- Publication Type:Journal Article
- Keywords:
attention deficit hyperactivity disorder;
methylphenidate;
alpha rhythm;
self-controlled study
- From:
Chinese Mental Health Journal
2002;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of stimulant medications on the EEG of children with attention deficit hyperactivity disorder(ADHD) by measuring the changes of the alpha competitive structure after administration of single dose of methylphenidate,and to explore the neuropathological mechanism of ADHD.Methods:The study involved 110 ADHD children who met the DSM-Ⅳ diagnostic criteria of ADHD and 110 normal children matched by age and sex.Their continuous EEG data were collected before and 2 hours after taking methylphenidate(10 mg) and were analyzed with EEG-encephaloflutuographic technology(EEG-ET).Results:(1)After taking methylphenidate,the main frequency of alpha band obviously increased [(8.97?0.94) Hz vs.(9.40?0.99) Hz,P0.05].Conclusion:Single dose methylphenidate can ameliorate the brain self-organization in ADHD children and improve the lower efficient state,and produce changes in the EEG towards normalization.
