Association Study of the Disrupted in Schizophrenia 1(DISC1)Gene Polymorphisms with Schizophrenia
- VernacularTitle:精神分裂症断裂基因1(DISC1)多态性与精神分裂症的关联研究
- Author:
Wei SUN
;
Jun YAN
;
Lifang WANG
;
Mei QU
;
Yanyan RUAN
;
Tianlan LU
;
Weihua YUE
- Publication Type:Journal Article
- Keywords:
schizophrenia;
disrupted in Schizophrenia 1(DISC1);
association study
- From:
Chinese Mental Health Journal
2002;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
T,P=0.008; Genotype:P=0.031)of DISC1 gene were significantly associated with schizophrenia.The haplotypes constructed by these two markers were significantly associated with schizophrenia,such as AT(?2=7.065,P=0.008,OR=1.42,95%CI=1.10~1.83)and GA(?2=6.009,P=0.014,OR=0.80,95%CI=0.68~0.96).When the subjects examined with the positive and negative syndrome scale(PANSS),the risk haplotype AT was not significantly correlated with positive,negative,excitement,depression and cognitive impairment factors of PANSS. Conclusion:These findings provide further evidence for DISC1 as a predisposing gene involved in schizophrenia in the Chinese Han Population.However,no positive association is found between DISC1 polymorphisms with schizophrenia clinical symptoms.
