Regulating effect of graft-versus-host-disease and graft-versus-leukemia
- VernacularTitle:移植物抗宿主病和移植物抗白血病的调控机制
- Author:
Dafa QIU
;
Xiaojun XU
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2007;0(31):-
- CountryChina
- Language:Chinese
-
Abstract:
Through thorough understanding of the pathophysiology of graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) effect, especial the effects of immune cells and cytokines, the article is designed to find out multiple ways to reduce GVHD and reserve or enhance GVL effect. Many kinds of cytokines are involved in the pathophysiologic mechanisms of GVHD and GVL effect. Different cytokines have different effects on GVHD and GVL effect. Immune cells play important roles in regulating GVHD and GVL effect. Studies shows that some cytokines and specific immune cells are able to reduce GVHD, as well as reserve or enhance GVL effect at the same time, which make the separation of GVL from GVHD can be achieved. On the whole, through thorough understanding of the mechanism of immune cells and cytokines in GVHD and GVL effect, we can find out multiple ways to reduce GVHD, as well as reserve or enhance GVL effect.
