Treatment of multiple organ dysfunction syndrome by administration of mesenchymai stem cells
10.3760/cma.j.issn.1673-4203.2009.05.003
- VernacularTitle:间充质干细胞移植治疗多器官功能不全综合征的研究
- Author:
Qiong SONG
;
Bin LING
;
Jie SUN
;
Ping LIU
- Publication Type:Journal Article
- Keywords:
mesenchymal stem cells;
multiple organ dysfunction syndrome;
lentiviral transfection
- From:
International Journal of Surgery
2009;36(5):294-297,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the bone marrow-derived mesenchymal stem cell(MSC) potential as seed cells for treatment of multiple organ dysfunction syndrome(MODS) in rabbit model, lay fundamental for clin-ical utilization of the MSC for treatment of MODS. Methods MODS rabbit model was established by hemor-rhagic shock combined with endotoxin, isolation and characterization of rabbit bone marrow mesenchymal stem cells labeled MSC with GFP by lentivirus transfection, administration of MSC by ear margin vein injec-tion, MSC integration determined by PCR and pathological section, the MSCs effect on MODS rabbits evalu-ated by physical observation. Results Compared with controls, ransplanted MSCs were found in liver, lung, kidney, MODS rabbits were physically improved obviously. Conclusions MSCs are able to integrate into host without any rejection reaction, and capable of ameliorating MODS evidently.
